SynTumor is a 3D tissue model for cell-cell and cell-drug interaction in a realistic tumor environment. Get as close as possible to in vivo experiments while controlling every aspect of the experimental conditions.
General
SynVivo's SynTumor is a system designed for the study of drug/endothelium, drug/tumor interaction in a realistic and dynamic tumor microenvironment. By reproducing a histological section of co-cultured tissue and/or tumor cells with an endothelial cell lumen, the SynVivo platform provides a physiologically realistic model including flow and shear in one platform, and allows real-time monitoring of binding and extravasation processes.
Starter Pack - To order the chip only, check our dedicated pages for linear, radial and microvascular designs (ref SY-102004, SY-102012, SY-108011, SY-108007, SY-105007, SY-105015).
Content
12x SynTumor chips (Choice of IMN2 radial, IMN2 linear or SMN2)
1x Pneumatic priming device (required for priming tubing to remove air)
1x Manifold (allows for multiple devices)
1x Tygon Tubing .02"ID X .06"OD (100 ft)
25x Slide Clamps
50x Blunt Tip Needles
50x 1mL Syringes with Luer-Lok® Tip
This kit does not include the air pump needed to establish the air-liquid interface.
Specifications
| IMN2 radial |
SMN2 co-culture microvascular network
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IMN2 linear |
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IMN2 radial chip with pillars (left) and slits (right)
- Tissue chamber: 1.8 mm diameter
- Depth: 100 μm
Slit version:
- Outer channel (OC): 100 μm
- Slit width (WS): 2 µm
- Slit spacing (SS): 50 µm
- Travel (T): 50 μm
Pillar version:
- Outer channel (OC): 200 μm
- Pillar spacing (SP): 8 µm
- Travel (T): 50 µm
- Pillar height: 8 µm
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Idealized co-culture chip microvascular network with pillar barrier, pillar height of 2 or 8 µm.
2 µm pillar height:
- Diameter: 20 µm
- Separation: 3 µm
- Depth: 100 µm
8 µm pillar height:
- Diameter: 10 µm
- Separation: 50 µm
- Depth: 100 µm
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Idealized co-culture network, 3 or 5 µm slits.
- Outer channels width (blue): 200 μm
- Central channel width (red): 500 µm
- Depth: 100 µm
- Travel width (distance between channels): 50 μm
- Slits width: 3 μm or 5 µm
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Documentation
?SynVivo brochure
?SynTumor idealized network technical manual
?SynTumor microvascular network technical manual
?SynVivo starter kit brochure
Vu, M. N., Rajasekhar, P., Poole, D. P., Khor, S. Y., Truong, N. P., Nowell, C. J., ... & Davis, T. P. (2019). Rapid assessment of nanoparticle extravasation in a microfluidic tumor model. ACS Applied Nano Materials, 2(4), 1844-1856. https://doi.org/10.1021/acsanm.8b02056
Pradhan, S., Smith, A. M., Garson, C. J., Hassani, I., Seeto, W. J., Pant, K., ... & Lipke, E. A. (2018). A microvascularized tumor-mimetic platform for assessing anti-cancer drug efficacy. Scientific reports, 8(1), 1-15. https://doi.org/10.1038/s41598-018-21075-9
Tang, Y., Soroush, F., Sheffield, J. B., Wang, B., Prabhakarpandian, B., & Kiani, M. F. (2017). A biomimetic microfluidic tumor microenvironment platform mimicking the EPR effect for rapid screening of drug delivery systems. Scientific reports, 7(1), 1-14. https://doi.org/10.1038/s41598-017-09815-9
Jarvis, M., Arnold, M., Ott, J., Pant, K., Prabhakarpandian, B., & Mitragotri, S. (2017). Microfluidic co‐culture devices to assess penetration of nanoparticles into cancer cell mass. Bioengineering & translational medicine, 2(3), 268-277. https://doi.org/10.1002/btm2.10079
Boohaker, R. J., Sambandam, V., Segura, I., Miller, J., Suto, M., & Xu, B. (2018). Rational design and development of a peptide inhibitor for the PD-1/PD-L1 interaction. Cancer Letters, 434, 11-21. https://doi.org/10.1016/j.canlet.2018.04.031
Prabhakarpandian, B., Shen, M. C., Nichols, J. B., Garson, C. J., Mills, I. R., Matar, M. M., ... & Pant, K. (2015). Synthetic tumor networks for screening drug delivery systems. Journal of controlled release, 201, 49-55. https://doi.org/10.1016/j.jconrel.2015.01.018
