This organ-on-a-chip design models a "vessel" bifurcation, a key element in endothelium biology and the onset of cardiovascular diseases. This device accurately mimics vascular geometries and physiological flow associated.
General
This "vessel-on-a-chip" system is ideal for gaining insight into vascular biology by modeling blood vessel geometry associated with a physiological flow of medium, cells, and/or particles or interest. The Y bifurcation exists with different options of bifurcation angles but also channel section types (semicircular or circular) and diameters. Bifurcation angle can be set up at 45°, 90°, or 135° allowing the study of a wide range of vascular geometries.
The circular channels enhance the physiological resemblance of the model to the human body to better decipher biological phenomena and test molecules.
These organ-on-chips devices are sold in packs of 3 chips with one Y design on each chip. The devices are made of PDMS and glass and are thus, autoclavable, biocompatible, gas permeable, and can be imaged with high optical quality.
Content
3x bifurcated chips
Specifications
Chips with bifurcation angle of 45°
| SKU |
B01_0025 |
B06_0022 |
B06_0019 |
B06_0016 |
| Bifurcation angle (°) |
45
|
| Channel diameter (mm) |
1
|
2
|
| Section shape |
Semicircular
|
Circular
|
Semicircular
|
Circular
|
| Inlet diameter (mm) |
3
|
| Inlet volume (µL) |
4.5
|
9
|
4.5
|
9
|
| Channel volume (µL)* |
25.8
|
51.5
|
51.5
|
103
|
| Channel length (mm)** |
32.8
|
| Chip thickness (mm) |
5.5
|
6.5
|
5.5
|
6.5
|
Chips with bifurcation angle of 90°
| SKU |
B01_0024 |
B06_0021 |
B06_0018 |
B06_0015 |
| Bifurcation angle (°) |
90 |
| Channel diameter (mm) |
1
|
2
|
| Section shape |
Semicircular
|
Circular
|
Semicircular
|
Circular
|
| Inlet diameter (mm) |
3
|
| Inlet volume (µL) |
4.5
|
9
|
4.5
|
9
|
| Channel volume (µL)* |
24.4
|
48.7 |
48.7 |
97.4 |
| Channel length (mm)** |
31.9
|
| Chip thickness (mm) |
5.5
|
6.5
|
5.5
|
6.5
|
Chips with bifurcation angle of 135°
| SKU |
B01_0025 |
B06_0022 |
B06_0019 |
B06_0016 |
| Bifurcation angle (°) |
135 |
| Channel diameter (mm) |
1
|
2
|
| Section shape |
Semicircular
|
Circular
|
Semicircular
|
Circular
|
| Inlet diameter (mm) |
3
|
| Inlet volume (µL) |
4.5
|
9
|
4.5
|
9
|
| Channel volume (µL)* |
22.8
|
45.3 |
45.3 |
91 |
| Channel length (mm)** |
28
|
| Chip thickness (mm) |
5.5
|
6.5
|
5.5
|
6.5
|
* Channel volume = central channel + two branches
** Channel length = central channel + one branch
Chip material: PDMS, a biocompatible silicone, optically compatible, oxygen breathable and autoclavable at 121°C.
Documentation
Find presentation and explanatory videos of BFlow products here.
Turpin C., Apalama M.L., Carnero B., Otero-Cacho A., Munuzuri A.P., Flores-Arias M.T., Vélia E., Meilhac O., Bourdon E., Alvarez E., Rondeau P. (2019). Impact of enhanced phagocytosis of glycated erythrocytes on human endothelial cell functions. Cells, 2(4), 1844-1856. https://doi.org/10.3390/cells11142200
Casa-Arozamena C., Otero-Cacho A., Carnero R., Almenglo C., Aymerich M., Alonso-Alconada L., Ferreiros A., Abalo A., Bao-Varela C., Flores-Arias M.T., Alvarez E., Munuzuri A.P., Abal M. (2021). Heemodynamic-dependent arrest of circulating tumour cells at large blood vessel bifurcations as new model for metastasis. Scientific Reports, 2(4), 1844-1856. https://doi.org/10.1038/s41598-021-02482-x
Otero-Cacho A., Aymerich M., Flores-Arias M.T., Abal M., Alvarez E., Perez-Munuzuri V., Munuzuri A.P. (2018). Determination of hemodynamic risk for vascular disease in planar artery bifurcations. Scientific Reports, 2(4), 1844-1856. https://doi.org/10.1038/s41598-018-21126-1
